Synthesis, Characterization, and Antimicrobial Properties of a New Ligand and Its Pd(II), Ru(II), Fe(II), Co(II) Complexes

Abstract

Schiff bases and their complexes are versatile compounds synthesized from the condensation of an amino compound with carbonyl compounds and widely used for industrial purposes and also exhibit a broad range of biological activities including antifungal, antibacterial, antimalarial, antiproliferative, antiviral, and antipyretic properties. In this study, the complexes of (E)-2-(3,5-di-tert-butyl-2-hydroxybenzylideneamino)-6-methyl4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile (L) with Co(II), Fe(II), Pd(II) and Ru(II) were successfully prepared. Structures of Schiff base and its metal complexes obtained were confirmed by FT-IR, 1H-NMR, 13CNMR, UV–vis, magnetic susceptibility, mass spectroscopy and elemental analysis. Antimicrobial activity of the synthesized Schiff base and its metal complexes have been studied. When the antimicrobial activities of the compounds were examined, it was observed that the lowest activity was exhibited by the ligand, and the highest activity was exhibited by the Co(II) and Pd(II) complexes. None of our compounds were been found to exhibit antifungal activity.

Schiff bazları ve kompleksleri, karbonil bileşikleri ile bir amino bileşiğinin kondenzasyonundan sentezlenen ve endüstriyel amaçlı yaygın olarak kullanılan ve ayrıca geniş bir aralıkta antifungal, antibakteriyel, antimalarial, antiproliferatif, antiviral ve antipiretik özellikler sergileyen çok yönlü bileşiklerdir. Bu çalışmada, (E)-2-(3,5-ditert-bütil-2-hidroksibenzilidenamino)-6-metil-4,5,6,7-tetrahidrobenzo[b]tiyofen-3-karbonitril (L) ile Co(II), Fe(II), Pd(II) ve Ru(II) kompleksleri başarıyla hazırlandı. Elde edilen Schiff bazı ve metal komplekslerinin yapıları FT-IR, 1H-NMR, 13C-NMR, UV-vis, manyetik süsseptibilite, kütle spektroskopisi ve element analiz yöntemleri ile belirlendi. Sentezlenen Schiff bazı ve metal komplekslerinin antimikrobiyal aktiviteleri çalışıldı.Antimikrobiyal aktivitelere bakıldığında en düşük aktiviteyi ligandın gösterdiği, en yüksek aktiviteyi ise Co(II) ve Pd(II) komplekslerinin gösterdiği görüldü. Maddelerimizin hiçbirinin antifungal aktivite göstermedikleri tespit edilmiştir.