Association of the phenolic content, DNA protective activity and some antioxidant properties in the Achillea arabica Kotschy Flower

Abstract

Pharmacological herbs are our first medicines in history and we take them into our bodies in different ways by consuming tea, spices, or raw. Nowadays, due to the side effects of more effective synthetic medicines, the tendency to use pharmacological plants has increased and the benefits are provided from plants in the treatment of routine diseases and to protect from them. In our daily life, stress and adverse environmental conditions may cause oxidative stress by increasing the concentration of reactive oxygen species (ROS) in a cell and oxidative stress is known to be associated with cancer and various neurodegenerative diseases such as Parkinson’s and Alzheimer’s. Antioxidants protect the cell against diseases by regulating the ROS concentration and herbal phenolics are known as antioxidants and strong candidates for this. In addition, studies on plant components and active ingredient have gained more importance during the Covid-19 epidemic period as they provide important data for vaccine development studies. In this study, it was aimed to obtain important data for advanced studies. For this purpose, Achillea arabica, one of the pharmacological members of the Asteraceae family, was collected from Ağrı/Patnos and stored by converting into herbarium material. Some biological activities such as the determination of some in vitro antioxidant properties, DNA protective activity, and the phenolic content by HPLC were evaluated in the DMSO extract prepared from the flowers of the herbarium plant. The results of the study were evaluated together and correlated.