Bir Diazenil Ligand: 4-[(Disiyanometil)]Benzoikasit: İle Metal Asetat Komplekslerinin Spektroskopik Karakterizasyonu ve Antibakteriyal Aktivitesi

Abstract

The new Pb(II), UO2(II), Cu(II), Ni(II), Co(II) and Zn(II) complexes were synthesized with the ligand containing the diazenyl group 4-[(dicyanomethyl)diazenyl]benzoic acid (L) which were prepared by the reaction of hydroxybenzaldehyde with 3-aminopropyltrimethoxysilane. The structure of the ligand and its complexes were determined by using elemental analysis, UV-visible, IR, H-NMR, 13C-NMR, TGA, DTA and magnetic measurements. The Co(II) and Ni(II) complexes are paramagnetic with octahedral structure; the Zn(II) complex is diamagnetic with octahedral structure; the Cu(II) complex is paramagnetic and have square planar structure; UO2(II) and Pb(II) complexes are diamagnetic and have square planar structure. All of the complexes were tested for their antibacterial activities against Escherichia coli ATCC-25922, Enterococcus faecalis ATCC 29212, Staphylococcus aureus ATCC 25923 and Salmonella typhimurium CCM 583. The test results were also evaluated. It was found that only Ni(II) and Zn(II) complexes are able to inhibit the growth of Staphylococcus aureus

3-Aminopropiltrimetoksisilan ve hidroksibenzaldehitin reaksiyonu sonucu diazenil grubu içeren 4-[(disiyanometil)diazenil]benzoikasit sentezlenerek yeni Pb(II), UO2(II), Cu(II), Ni(II), Co(II) ve Zn(II) kompleksleri sentezlendi. Ligand ve komplekslerin yapıları elemental analiz, UV-vis., IR, 1H-NMR, 13C-NMR, TGA, DTA ve magnetik ölçümler kullanılarak belirlendi. Co(II) ve Ni(II) kompleksler paramagnetik olup oktahedral, Zn(II) kompleksi diamagnetik olup oktahedral, Cu(II) kompleksi paramagnetic olup kare düzlem, UO2(II) ve Pb(II) kompleksler diamagnetic olup karedüzlem yapıya sahiptirler. Tüm komplekslerin antibakteriyel aktiviteleri Escherichia coli ATCC- 25922, Enterococcus faecalis ATCC 29212, Staphylococcus aureus ATCC 25923 ve Salmonella typhimurium CCM 583’e karşı testedildi. Test sonuçları değerlendirildi. Bu sonuçlardan sadece Ni(II) and Zn(II) komplekslerinin Staphylococcus aureus’un büyümesini inhibe ettiği görülmüştür.