Effects of electroporation on cytotoxicity of 4-aminopyrimidin-2-(1H)-one based ligand and its Cobalt (II) and Ruthenium (II) complexes in MCF-7 cancer cells

Abstract

Objective: The aim of this study was to investigate the underlying causes of obstetrical disseminated intravascular coagulation (DIC) Objective: Cancer is a complicated disease and ranks near the top among the causes of death across the world. Electrochemotherapy (ECT) is a local treatment method in which chemotherapy and electroporation (EP) are used in combination to facilitate the entry of drugs into cells. The purpose of the study is to examine the cytotoxicity of the cytosine-based ligand and its cobalt and ruthenium complexes in MCF-7 cancer cells and L-929 healthy cells, and to determine the effects of EP on the anticancer activities of these compounds.